Bio-imaging

Developing Novel Imaging and Sensing for Biomedical Research

◆ Single cell imaging

“Single cells and intracellular processes studied by a plasmonic-based electrochemical impedance
microscopy,” Nature Chemistry, 2011.

◆ Small molecule-membran receptor interaction

“Kinetics of Small Molecule Interactions with Membrane Proteins in Single Cells Measured with
Mechanical Amplification” Science Advances, 2015

◆ Drug Screening

“Detection of Charges and Molecules with Self-assambled Nano-oscillators”, Nano Letters, 14
(7), pp 4151-4157, 2014.

Related publications:

  • Yan Guan, Xiaonan Shan, Fenni Zhang, Shaopeng Wang, Hong-Yuan Chen Nongjian Tao, “Kinetics of Small Molecule Interactions with Membrane Proteins in Single Cells Measured with Mechanical Amplification”, Science Advances, Vol. 1, no. 9, Oct. 2015.
  • Yunze Yang, Hui Yu, Xiaonan Shan, Wei Wang, Xianwei Liu, Shaopeng Wang, Nongjian Tao, “Label-free Tracking of Single Organelle Transportation in Cells with Nanometer Precision Using a Plasmonic Imaging Technique”, Small, 11 (24), pp 2877, 2015.
  • Karan Syal, Wei Wang, Xiaonan Shan, Shaopeng Wang, Hong-Yuan Chen, Nongjian Tao, “Plasmonic Imaging of Protein Interactions with Single Bacterial Cells”, Biosensors and Bioelectronics, Volume 63, pp. 131-137, 2015.
  • Xiaonan Shan, Yimin Fang, Shaopeng Wang, Yan Guan, Hong-Yuan Chen and Nongjian Tao, “Detection of Charges and Molecules with Self-assambled Nano-oscillators”, Nano Letters, 14 (7), pp 4151-4157, 2014.
  • Hui Yu, Xiaonan Shan, Shaopeng Wang, Hong-yuan Chen, Nongjian Tao. “Plasmonic Imaging and Detection of Single DNA Molecules”, ACS Nano, 8(4), pp 3427-3433, 2014.
  • Hui Yu, Xiaonan Shan, Shaopeng Wang, Hong-Yuan Chen, Nongjian Tao, “Molecular Scale Origin of Surface Plasmon Resonance Biosensors”, Analytical Chemistry, 86 (18), pp 8992-8997, 2014.
  • Yan Guan, Xiaonan Shan, Shaopeng Wang, Peiming Zhang, Nongjian Tao, “Charge Sensitive Detection for Label-free and High-throughput Study of Molecular Interactions”, Chemical Science, 5 (11), pp 4375-4381, 2014.
  • Wang, K. Foley, Xiaonan Shan, S. P. Wang, S. Eaton, V. J. Nagaraj, P. Wiktor, U. Patel, N. J. Tao, “Single cells and intracellular processes studied by a plasmonic-based electrochemical impedance microscopy,” Nature Chemistry, vol. 3, pp. 249-255, Mar 2011.
  • Jin Lu, Wei Wang, Shaopeng Wang, Xiaonan Shan, Jinghong Li, Nongjian Tao, “Plasmonic-Based Electrochemical Impedance Spectroscopy: Application to Molecular Binding” Analytical Chemistry, 2012, 84 (1), pp 327–333
  • Shaopeng Wang, Xiaonan Shan, Urmez Patel, Xinping Huang, Jin Lu, Jinghong Li, Nongjian Tao,”Label-free imaging, detection, and mass measurement of single viruses by surface plasmon resonance,” Proceedings of the National Academy of Sciences, 107, pp. 16028-16032, August 26, 2010 2010.

Bio-research Instruments: